Bone Abstracts

New treatment agents against osteoporosis may not only lead to an improved trabecular structure, but can probably also strengthen the cortex. To assess this treatment effects by means of QCT, one has to deal with significant partial volume effects observing this very thin, but compact structure. A new method for cortical thickness estimation has been developed using an analytical deconvolution approach. After estimating the point-spread-function (PSF) of a scanner/kernel combi...

Quantitative Computed Tomography (QCT) can be performed with different protocols. We investigated whether selection of spatial resolution, reconstruction method, and scanner type have an impact on measured treatment effects for different bone compartments.Methods: In a multi-center study, a group of 50 men, age 55.1 (range 25–78) undergoing 18 months of either osteoanabolic (n=25) or antiresorptive treatment (n=25) were scanned wit...

Degradable bone implants may provide improved long-term healing, tissue remodeling and quality of life. In order to optimize alloy composition and degradation properties, in-vivo monitoring of the degradation process and its impact on bone formation is essential because degradation progresses differently in-vivo versus in-vitro. We aim to understand how degradation of magnesium alloy implants influences bone remodeling and bone structure using Micro-...

The concept of the vicious cycle of bone metastases emphasizes the cross-talk between osteoclasts, osteoblasts and tumor cells, but the role of bone marrow stromal cells (BMSCs) is not well delineated. BMSCs comprise of a fibroblast-like cell population which adhere to culture flask and have an ability to differentiate into osteoblasts, adipocytes and chondrocytes. They express a panel of cell surface antigens which includes CD105, CD73, CD90, CD106, and CD146. In this study w...

Bone mineral density (BMD) as measured by quantitative computed tomography (QCT) is biased by the variable marrow composition since marrow fat reduces the apparent BMD. We developed a marrow densitometry (MD) method that identifies subvolumes in the vertebrae that consist of bone marrow only (bone voids) and determines their average mineral equivalent density values. The method was developed for use with in vivo high resolution QCT (HR-QCT). HR-QCT still has limited s...